12 things in your home that Lead to Heart Disease
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14 Ways Mycotoxins Lead to Cardiovascular Disease

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Cardiovascular disease (CVD) remains the leading cause of deaths worldwide, despite billions of dollars spent on pharma each year. This is a catastrophe. Recently, studies have shed light on a novel cause of CVD – mold mycotoxins. These toxic compounds produced by molds have been implicated in a variety of health issues.

So, health problems like heart attacks, strokes, AFIB, POTS and cardiomyopathy MUST be understood in light of the mold (and bacteria) from water-damaged buildings. 

In this article, we look at 14 different ways that mold mycotoxins contribute to the development and progression of cardiovascular disease.

1) Alterations to the Gut Microbiome

First, the gut microbiome plays a crucial role in maintaining overall health, including cardiovascular health. Mold mycotoxins can disrupt the balance of the gut microbiota, leading to dysbiosis. Dysbiosis, in turn, has been associated with inflammation and metabolic disturbances, both of which are key factors in the development of cardiovascular disease.

2) Intestinal Hyperpermeability (Leaky Gut)

Mold mycotoxins have been shown to increase intestinal permeability, commonly referred to as “leaky gut.” A compromised gut barrier allows harmful substances, including toxins and pathogens, to enter the bloodstream, triggering an inflammatory response. This chronic inflammation is a known contributor to the development of cardiovascular diseases.

3) Decreased Glutathione Levels

Glutathione, a potent antioxidant, plays a crucial role in protecting cells from oxidative stress. Mold mycotoxins can deplete glutathione levels, leaving cells vulnerable to oxidative damage. This reduction in antioxidant capacity may contribute to the oxidative stress implicated in cardiovascular diseases.

4) Inflammation

Chronic inflammation is a well-established factor in cardiovascular disease. Mold mycotoxins can activate inflammatory pathways, leading to the production of pro-inflammatory cytokines. This sustained inflammatory response can contribute to the progression of atherosclerosis and other cardiovascular conditions.

5) Oxidative Stress and Lipid Peroxidation

Oxidative stress, resulting from an imbalance between reactive oxygen species (ROS) and antioxidants, is a hallmark of cardiovascular diseases. Mold mycotoxins can induce oxidative stress, leading to lipid peroxidation – a process that damages cell membranes and contributes to atherosclerosis.

6) Endothelial Dysfunction

The endothelium, the inner lining of blood vessels, plays a crucial role in maintaining vascular health. Mold mycotoxins have been implicated in endothelial dysfunction, impairing the production of nitric oxide and promoting vasoconstriction. Endothelial dysfunction is a key early event in the development of cardiovascular diseases.

7) LDL Receptor Dysfunction

Low-density lipoprotein (LDL) receptors are responsible for clearing cholesterol from the bloodstream. Mold mycotoxins can interfere with LDL receptor function, leading to elevated levels of LDL cholesterol. High LDL cholesterol is a well-known risk factor for atherosclerosis and cardiovascular diseases.

8) Apoptosis

Mold mycotoxins can induce apoptosis (cell death), in various cell types. Excessive apoptosis in cardiovascular tissues can contribute to the development of atherosclerosis, myocardial infarction, and other cardiovascular conditions.

9) Protein/RNA/DNA Synthesis Inhibition

Mold mycotoxins can interfere with cellular processes, including the synthesis of proteins, RNA, and DNA. These disruptions can lead to mutations and aberrant cell function, potentially contributing to the development of cardiovascular diseases.

10) Decreased Nitric Oxide Production

Nitric oxide (NO) is a key vasodilator and anti-inflammatory molecule produced by the endothelium. Mold mycotoxins have been shown to decrease NO production, leading to impaired vascular function and promoting the development of cardiovascular diseases.

11) Immune-Dysregulation

The immune system plays a crucial role in maintaining cardiovascular health. Mold mycotoxins can damage the immune response, leading to chronic inflammation, thus contributing to the pathogenesis of cardiovascular diseases.

12) Mitochondrial Dysfunction

Mitochondria, the energy-producing organelles within cells, link their dysfunction to various diseases, including cardiovascular conditions.Mold mycotoxins can disrupt mitochondrial function, potentially contributing to energy imbalance and cellular damage in cardiovascular tissues.

13) Autonomic Dysfunction

The autonomic nervous system regulates heart rate, blood pressure, and other cardiovascular functions. Mold mycotoxins may disrupt autonomic function, leading to imbalances that can contribute to the development of cardiovascular diseases.

14) Coagulation Abnormalities

Associations between mold mycotoxins and alterations in the coagulation cascade have led to increased blood clotting. Obviously, excessive blood clotting is a risk factor for thrombotic events, such as heart attacks and strokes, contributing to the overall burden of cardiovascular diseases.

Next Steps

You need to know if a water damaged building is exposing you to mold and bacteria. PLEASE do not assume that you are safe. Just test yourself and your home. 

Here are the next two steps:

  1. Urine mycotoxin testing: Are there mold mycotoxins in your urine? So, if they are coming IN your body, if they are coming out of your body. – Buy the urine mycotoxin test here.
  2. #8 swiffer test: A very comprehensive, do-it-yourself test for mold AND bacteria in your home. We recommend EVERYONE test their home with this. – Buy the swiffer test here.

These tests include a free review call to go over the results. 

Finally, please check for mold soon. The health of you, your family, and your pets depends on knowing this information.


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Dr. Smigiel helps people suffering from conditions such as chronic pain and erectile dysfunction, to hair loss and weight gain. Combining treatments such as PRP Therapy, Ozone, Neural Prolotherapy, and IV Infusions with functional rehabilitation, he helps you look and feel better.

He heals the body, instead of just treating the symptoms!

With his professional qualifications as a certified family nurse practitioner, a doctor of chiropractic, and a fellow of the International Academy of Medical Acupuncture, Dr. Smigiel offers patients comprehensive care from a broad perspective of conventional and alternative medicine. He also has extensive experience in functional rehabilitation and chronic pain management.

Dr. Smigiel is married to Angela and has two children, Sophia and Larz. When he’s not busy helping patients, he enjoys hiking, mountain biking, motocross, and boating.

About Dr. James Kneller, M.D., Ph.D., FHRS

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Dr. James Kneller is one of the nation’s leading heart rhythm specialists. Dr. Kneller is certified by the American Board of Internal Medicine (ABIM) in Clinical Cardiac Electrophysiology, Cardiovascular Disease, and Internal Medicine.

As a Fellow of the Heart Rhythm Society (FHRS) and Certified Cardiac Device Specialist (CCDS), Kneller provides comprehensive patient care, combining best medical practice with invasive procedures using state-of-the-art technologies to treat heart rhythm disorders.

Beyond guideline-directed therapies, Kneller is passionate about optimized personal health. With a deep interest in complimentary alternative medicine (CAM), he strives to reduce the need for pharmaceuticals, invasive procedures, and exposure to harmful radiation. With Natural Heart Doctor, he strives to help each and every client to Live Well, Eat Well, and Think Well to attain their 100-year heart!

About Dr. Lauren Lattanza NMD, FACC

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As a Naturopathic Physician, I am trained to treat the whole person and get to the root cause of disease.

I went to Arizona State University where I graduated with a bachelor’s degree in psychology with a depth in physiology and minor in Spanish. After my undergraduate degree I was working on prerequisite classes towards medical school, which is when I came to learn that my values identified best with the principles of naturopathic medicine. I knew that I wanted to help patients identify the causes of disease and be able to offer treatments which would improve their health rather than simply treating symptoms.

I dedicated the next 4 years to the Southwest College of Naturopathic Medicine in Tempe, Arizona where I attained my Doctorate of Naturopathic Medicine. I served as Class President all 4 years, Board of Trustees – Student Trustee, spoke as the Club President for our branch of Toastmasters, and was voted by my peers and attending physicians to earn the Outstanding Leadership Award for the Class of 2020. Throughout medical school I took it upon myself to work alongside MDs, DOs, chiropractors, and functional medicine practitioners in addition to naturopathic physicians.

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About Dr. Jack Wolfson DO, FACC

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Dr. Jack Wolfson is a board-certified cardiologist, Amazon best-selling author, husband, father, and the nation’s #1 Natural Heart Doctor.

For more than two decades, more than one million people have enjoyed the warmth, compassion, and transformational power of his natural heart health courses and events.

Dr. Wolfson is the founder of Natural Heart Doctor Scottsdale, his heart health practice in Arizona, and Natural Heart Doctor, an online resource center with natural health information. Doctors from across the globe reach out to Dr. Wolfson for training and education in holistic health practices.

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Our health coaches use evidence based skillful conversation, clinical interventions, and strategies to engage you actively and safely in health behavior changes.

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Schedule an office visit with one of our cardiologists, holistic physicians, chiropractor, or health coaches.

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Frequently Asked Questions

I’d like to receive an online second opinion from Natural Heart Doctor. What do I do next?

You can initiate a second opinion online through our website at any time. To begin, select the team member you’d like to speak with and open an account.

Click here for cardiologist Dr. Jack Wolfson.

Naturopathic Medical Doctor Dr. Lauren Lattanza. Get details.

Naturopathic Medical Doctor Dr. Tonia Rainier. Get details.

Click here for  Natural Heart Doctor Health Coach.

Alternatively, you can email health@naturalheartdoctor.com. A member of our care team will help guide you through the process of starting a second opinion.

What is the cost of a Natural Heart Doctor Online Second Opinion?

The cost for most second opinions varies by team member. This fee includes information collection, a phone or video consultation, a second opinion from a Natural Heart Doctor specialist and guidance throughout the process from your personal Care Team at Natural Heart Doctor.

Cardiologist Dr. Jack Wolfson’s Second Opinion Fee is $1500.

Holistic Physician’s Dr. Lauren Lattanza’s Second Opinion Fee is $250.

Naturopathic Physician Dr. Tonia Rainier’s Second Opinion Fee is $250.

Note: We apply the Online Second Opinion Call fee as a credit to any future consultations with Natural Heart Doctor, should you choose them.

Will my insurance cover the cost of a Natural Heart Doctor Online Second Opinion?

Most likely, no. Most health plans do not cover online second opinions or consultations. You are responsible for the cost of our second opinion. Natural Heart Doctor cannot file a claim with your insurance carrier, nor can we provide a procedure (CPT) code for this service.

What is the timeline to receive an online second opinion?

We do our best to schedule your second opinion as quickly as possible. Typically, it takes 5 to 7 business days after your information has been collected to receive your phone or video online second opinion.

What information do you need in advance of our call?

Our office will send you a short questionnaire to complete and return. We DO NOT need your complete medical records.

How many questions can I ask the expert during our call?

You may ask a maximum of five questions. This is to ensure that the expert has sufficient time to devote to each question. All questions must be finalized before your online meeting.

What should I expect to receive once my second opinion is complete?

You will receive a summary of our discussion along with our second opinion. The second opinion will be in written form. After you have reviewed the second opinion, a Natural Heart Doctor clinician will follow up with you by phone to address general medical questions about the information provided in the second opinion.

What if I have follow-up questions for the expert after I have reviewed my second opinion?

If you have a clarifying question about an expert’s response to one of the questions in your second opinion, and the Natural Heart Doctor clinician is unable to address it, then you may request a follow up session for an additional fee. 

Is my medical and payment information secure?

Natural Heart Doctor is strongly committed to protecting the privacy and security of all our patients. Our website meets all federal requirements for protecting personal health information under the Health Insurance Portability and Accountability Act (HIPAA). All financial transactions are processed by Natural Heart Doctor securely using industry standard payment processing tools.

I would rather visit Natural Heart Doctor for an in-person appointment. What should I do next?

If you would prefer an in-person appointment at Natural Heart Doctor instead of an online second opinion, please call (480) 535-6844 for details and scheduling.

Can I schedule a follow up appointment with the specialist who provided my online second opinion?

Yes, we’re happy to help you on an extended basis. Our clinician can discuss options with you when presenting our second opinion summary.