Familial or Hereditary Hyperlipidemia (hypercholesterolemia) is a significant health concern that affects numerous individuals globally, but overall a small percentage of people. This condition, often inherited, is characterized by abnormally high levels of cholesterol in the blood, particularly low-density lipoprotein cholesterol (LDL-C) over 300 and total cholesterol over 400.
The most common genetic variations are found in the LDL receptor (LDLR) gene, which plays a crucial role in regulating cholesterol levels in the body. Mutations in this gene result in either reduced numbers or malfunctioning of LDL receptors on liver cells, leading to an accumulation of LDL in the blood.
Other genetic mutations include those in the apolipoprotein B (APOB) gene and the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene. APOB is a component of LDL particles, and mutations here can affect the way LDL is metabolized. PCSK9 mutations can lead to increased degradation of LDL receptors, further exacerbating high LDL levels.
Diagnosis of familial hyperlipidemia (FH) is often based on a combination of family history, physical examination findings (such as the presence of xanthomas, which are cholesterol deposits in the skin), and lipid profile tests. Genetic testing is also increasingly being used to confirm the diagnosis, but I find this testing unnecessary as it does not change my treatment approach.
The NHD Approach to Familial Hyperlipidemia
Let me start with this disclaimer. I do not follow the “guidelines”, so ask your MD before embarking on any approach different from mainstream.
Just about all cardiologists will recommend statin drugs, PCSK9 inhibitors such as Repatha, and products like ezetimibe (Zetia). I don’t recommend these drugs. I recommend Eat Well, Live Well, Think Well, then Test Don’t Guess, evidence-based supplements and biohacking strategies.
The main approach here is to upgrade liver functionality to assist in the removal of old LDL particles. Binding lipids in the gut is an additional approach.
Two products that I like to support optimal lipid levels include:
- OptiLipid 2 caps 2x per day for people with familial hyperlipidemia (FH)
- Daily Defense 2 scoops per day.
You may also want to add an additional tablespoon of organic psyllium husk powder from THIS source to your daily routine. We use this inside our Daily Defense, but patients with FH often require more.
The above may be combined with pharma.
Pharma is not the best strategy. Work with us to learn more about how to deal with FH and really prevent heart attacks, stroke, and an untimely exit from life. Schedule your free coaching discovery call here.