Authors of a recent study gave Arterosil to six patients with atherosclerotic plaque in their carotid arteries. Plaque in the carotid likely means plaque in the coronary arteries as well. So if you can reduce carotid plaque, you can reduce coronary plaque.
This plaque was discovered using a standard ultrasound test called carotid intima-media thickness (CIMT). This test measures the thickness of the artery walls by looking at the layers inside the artery.
The patients joined a functional medicine program focused on preventing heart problems by addressing the root causes. The program included personalized treatments such as medications, dietary supplements, and lifestyle changes. While these approaches helped manage their symptoms and risk factors, the carotid plaque remained unchanged.
The authors then added a natural dietary supplement, Arterosil, to their treatment plan. This supplement is designed to repair the endothelial glycocalyx, a protective layer in the arteries. It contains rhamnan sulfate, an extract from the green seaweed Monostroma nitidum. The patients took the supplement daily, and after six months, their plaque levels were measured again using the same CIMT test.
All six patients showed a decrease in their plaque levels, with an average reduction of 5.55 mm, which is a significant improvement. The maximum thickness of the plaque also decreased noticeably.
This study suggests that rhamnan sulfate from Monostroma nitidum may be a safe and effective way to reduce artery plaque and could be a helpful addition to treatments for preventing and managing heart disease.
Additional Comments
Atherosclerosis remains a challenging disease due to its complex pathology. Current research highlights the “response to injury theory,” which views atherosclerosis as an inflammatory response to endothelial damage. This process, termed Leaky Artery Syndrome, involves LDL penetration into the endothelium, triggering oxidation and foam cell formation, plaque development, and inflammation. A novel focus in understanding atherogenesis is the endothelial glycocalyx (EGX), a protective, gel-like barrier on the vascular endothelium with anti-inflammatory, anticoagulant, and antioxidant properties. EGX damage, caused by factors such as high blood glucose and oxidative stress, is prominent at atheroprone sites like arterial bifurcations.
The dietary supplement Arterosil HP, containing rhamnan sulfate (RS) derived from Monostroma nitidum, has shown promise in regenerating EGX and reducing carotid plaque burden. RS enhances EGX integrity, reduces LDL permeability, and exhibits anti-inflammatory and anti-thrombotic properties. In studies, RS reduced vascular inflammation, inhibited smooth muscle proliferation, and decreased plaque deposition and stenosis in animal models. It also improved endothelial nitric oxide production, which aids vascular health. Clinical evidence from a six-month intervention with Arterosil HP demonstrated substantial plaque regression in participants, even in the presence of normal cholesterol levels, underscoring EGX’s critical role in plaque development.
Small, dense LDL particles, which are more atherogenic due to increased oxidizability and endothelial penetration, may also contribute to atherosclerosis risk beyond cholesterol levels. By reducing LDL passage through the endothelium, a robust EGX complements existing cholesterol-lowering therapies.
Anti-inflammatory therapy is pivotal in reversing atherosclerosis, and RS’s inhibition of NF-ĸB signaling and promotion of efferocytosis are key mechanisms. Though inflammation biomarkers remained unchanged in participants, the EGX’s anti-inflammatory effects were evident.
Although the study was a small one, I think integrating Arterosil HP into a systems-based cardiology prevention program has shown potential to stabilize and reverse atherosclerotic plaque safely.
I have not seen any complications or side effects while taking Arterosil.
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