Ozempic (semaglutide) is a medication primarily used to treat type 2 diabetes. It belongs to a class of drugs known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs). These medications are often prescribed to help control blood sugar levels in people with diabetes by stimulating insulin release and reducing glucagon secretion in response to meals.

Here are some generic names for this class of drugs exenatide, lixisenatide, liraglutide, albiglutide, dulaglutide, tirzapatide (Mounjaro) and semaglutide.

While Ozempic is not primarily indicated for improving heart health, there is evidence to suggest that some GLP-1 RAs, including semaglutide (Ozempic), may have beneficial effects on the cardiovascular system. This is particularly important because individuals with type 2 diabetes are at an increased risk of heart disease.

How Does Ozempic Work?

Ozempic (semaglutide) is a medication used to treat type 2 diabetes, and it belongs to a class of drugs known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs). It works in several ways to help control blood sugar levels and has some additional effects on body weight and appetite. Here’s how Ozempic works:

• Stimulates Insulin Release: Ozempic mimics the action of a hormone called glucagon-like peptide-1 (GLP-1), which is naturally produced in the intestines. When you eat, GLP-1 is released, and it stimulates the pancreas to release insulin. Insulin helps regulate blood sugar levels by facilitating the uptake of glucose into cells.
• Inhibits Glucagon: In addition to stimulating insulin release, GLP-1 also inhibits the release of another hormone called glucagon. Glucagon promotes the release of glucose from the liver. By inhibiting glucagon, Ozempic helps reduce the amount of glucose released into the bloodstream.
• Slows Gastric Emptying: Ozempic also slows down the rate at which the stomach empties its contents into the intestines. This delay in gastric emptying can help reduce post-meal spikes in blood sugar levels. (risk of gastroparesis)
• Reduces Appetite: Some GLP-1 RAs, including Ozempic, have been associated with a reduction in appetite. This can lead to weight loss in some individuals, which can be beneficial for those who are overweight or obese.

The net result of these actions is improved blood sugar control, as Ozempic helps lower fasting and post-meal blood glucose levels. It also has the potential to reduce the risk of hypoglycemia (low blood sugar), as it primarily works when blood sugar levels are elevated.

Ozempic and Your Heart

Several clinical trials have evaluated the cardiovascular effects of Ozempic and other GLP-1 RAs. In some of these trials, they have shown a reduction in major adverse cardiovascular events (MACE), which include heart attacks, strokes, and cardiovascular death. For example, the SUSTAIN-6 trial demonstrated a significant reduction in MACE for semaglutide compared to a placebo. In SUSTAIN-6, a 1% reduction in non-fatal heart attacks and a 1% stroke reduction was seen. There was no cardiovascular mortality benefit and no overall death benefit.

The exact mechanisms through which GLP-1 RAs like Ozempic have cardiovascular benefits are not fully understood but may involve actions such as reducing inflammation, improving blood vessel function, and promoting weight loss.

A recent 2023 trial found Ozempic to benefit people with heart failure, normal ejection fraction, and obesity. Inflammation was lower and symptoms improved.

Risks of Ozempic

Some of the potential risks and side effects associated with Ozempic:

• Hypoglycemia: While Ozempic itself is less likely to cause hypoglycemia (low blood sugar) compared to some other diabetes medications, there is still a risk of low blood sugar when used in combination with other medications that lower blood sugar.
• Pancreatitis: There have been rare reports of pancreatitis (inflammation of the pancreas) associated with Ozempic. Symptoms can include severe abdominal pain, often radiating to the back, and you should contact your healthcare provider immediately if you experience these symptoms.
• Thyroid Tumors: Some studies in animals have shown an increased risk of thyroid tumors with GLP-1 receptor agonists like Ozempic. However, this risk and its relevance to humans are still being investigated.
• Allergic Reactions: Although rare, some individuals may experience allergic reactions to Ozempic, such as itching, rash, or swelling. Seek medical attention if you experience any severe allergic reactions.
• Kidney Function: There have been reports of changes in kidney function in some individuals using Ozempic. Your healthcare provider will monitor your kidney function while you are on medication.
• Heart Rate Increase: GLP-1 RAs like Ozempic may cause a small increase in heart rate.
• Injection Site Reactions: As Ozempic is administered via subcutaneous injection, there may be mild redness, itching, or pain at the injection site.

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The Better Way instead of Ozempic

The better way is not the easy way, but this path goes after the causes of disease. Your body is not deficient in Ozempic or the others. Your body is deficient in Eat Well, Live Well, Think Well.

Remember, the goal is not to reduce your heart attack risk from 4% to 3%. The goal is 0%. We know mainstream does not offer this. I believe we do at Natural Heart Doctor. Schedule a free coaching session HERE to find out more how to reduce your risk while experiencing vitality, clarity and longevity.