Nattokinase is gaining attention in the natural health world, especially for heart and circulatory wellness. Derived from natto—a traditional Japanese fermented soybean dish—this powerful enzyme has been studied for its effects on blood clotting, blood pressure, and more. We love this ingredient so much, we combine it into our synergistic product called FLOW.
But with its growing popularity, questions often arise. Let’s tackle the most common FAQs about nattokinase.
1. What exactly is nattokinase?
Despite its name, nattokinase is not a “kinase” enzyme but rather a serine protease—a type of enzyme that breaks down proteins. It’s produced by Bacillus subtilis natto during the fermentation process of soybeans. Its main claim to fame is its fibrinolytic activity, meaning it can help break down fibrin (the protein that forms blood clots).
2. How can nattokinase support cardiovascular health?
Nattokinase is most often used to support:
- Healthy blood pressure levels
- Circulation and blood flow
- Clot prevention and breakdown
- Arterial flexibility
Studies suggest it may help reduce both systolic and diastolic blood pressure, and it enhances the body’s natural clot-dissolving systems. Many people turn to it as a natural complement to their heart health strategy.
3. Is nattokinase safe? Are there side effects?
For many, nattokinase is well-tolerated. However, it comes with important cautions:
- It may increase bleeding risk, especially if taken with blood thinners (like warfarin), antiplatelet drugs (like aspirin), or in people with clotting disorders.
- Rare side effects may include dizziness, allergic reactions, or gastrointestinal upset.
- Pregnant or breastfeeding women should avoid nattokinase due to a lack of safety data.
As with any supplement, it’s best to discuss use with a trusted health professional.
4. How much nattokinase should I take?
Clinical trials have used a wide range of doses, from 1,200 FU to over 10,000 FU daily (FU = fibrinolytic units). Most common supplements provide 2,000 FU per capsule, often taken once or twice daily.
Because supplement quality can vary, look for brands that undergo independent third-party testing to verify potency and purity.
5. Does nattokinase have benefits beyond the heart?
Yes—early research points to broader applications:
- Brain health: Some studies suggest it may help degrade amyloid fibrils associated with Alzheimer’s.
- Stroke recovery: Its clot-dissolving activity could offer neuroprotective effects.
- Digestive & inflammatory conditions: Animal studies hint at potential in inflammatory bowel disease and cancer-related clotting, though human evidence is still limited.
More research is needed, but nattokinase continues to show exciting promise.
6. How does nattokinase compare to prescription blood thinners?
Unlike drugs such as warfarin or aspirin, nattokinase is a natural enzyme that works with the body’s own clot-dissolving pathways. However, it is not a substitute for prescribed anticoagulant therapy. If you are on such medications, you must be cautious and consult your physician before adding nattokinase.
The Bottom Line
Nattokinase is a fascinating natural compound with potential benefits for cardiovascular health and beyond. While it may support healthy blood pressure and circulation, it also carries risks—especially when combined with blood-thinning drugs. Choosing a high-quality supplement and personalizing your dose under expert guidance are essential.
That’s why at Natural Heart Doctor, we created FLOW, a unique formula that combines Nattozimes® (4,516 FU) with Serrapeptase (20,000 U). Together, these powerful enzymes work in synergy:
- Nattokinase helps support healthy blood pressure and circulation by breaking down excess fibrin and promoting clot balance.
- Serrapeptase, another potent proteolytic enzyme, helps clear away inflammatory proteins and debris, supporting vascular flexibility, tissue repair, and a healthy inflammatory response.
When combined, they create a one-two punch for optimal circulation, reduced inflammation, and overall cardiovascular resilience.
FLOW Supplement Facts
Suggested Use: Take 1 capsule twice daily, away from food, or as directed by your healthcare professional.
FLOW embodies our mission to deliver science-backed, natural solutions that support your 100 Year Heart lifestyle—helping you live longer, stronger, and healthier without pharmaceuticals.
