In recent years, there has been growing interest in traditional or alternative wellness practices that might support cardiovascular health. One of these is oil pulling—swishing oil in the mouth—and even more specifically, using ozonated fixed oils. Companies like PurO3 are offering ozonated oil pulling solutions that infuse coconut, sesame, sunflower oils (plus organic peppermint for taste) with activated oxygen (ozone).
Below we look at how oil pulling with ozonated oils might contribute positively to four cardiovascular-health areas: blood pressure control, lowering inflammation, reducing oxidative stress, and improving lipid profiles. We’ll also discuss what the science currently says—and where it doesn’t yet.
What is PurO3’s Ozonated Oil Pulling Solution
Here’s a brief recap of what the product is and how it’s used:
- Combines organic coconut, sesame, and sunflower oils, infused with ultrapure ozone; flavored gently with peppermint.
- Meant for daily oil pulling: swish ~1 teaspoon (≈10 ml) for 10–15 minutes, then spit out, rinse, then follow up with brushing.
- Designed without additives like synthetics or fillers; stored in a cool, dry place; long-term storage may benefit from refrigeration.
The idea is that the ozonated oil can do more than just mechanically pull toxins / microbes; the ozone infuses the oil (through formation of ozonides & peroxides) so that when used in the mouth it may impart antimicrobial, anti-inflammatory, antioxidant benefits. (MDPI)
Why Cardiovascular Health Could Benefit
Here are the plausible mechanisms by which ozonated oil pulling might help with cardiovascular health:
- Improving Endothelial Function / Blood Pressure
- The endothelium (lining of blood vessels) plays a critical role in regulating blood pressure, by releasing nitric oxide (NO) and balancing constriction/dilation. Oxidative stress and inflammation damage the endothelium, reducing NO and increasing stiffness.
- If ozonated oil pulling reduces microbial load and inflammation in the oral cavity, that could lower systemic inflammatory burden. Chronic oral infections (e.g. periodontitis) are known risk factors for hypertension and endothelial dysfunction.
- Also, ozone in ozonated oils has been studied in other contexts (e.g. topical or dietary) for possible effects on vascular tone. While direct human trials of ozonated oil pulling and blood pressure are lacking, reducing oxidative stress and inflammation tends to help with BP control.
- The endothelium (lining of blood vessels) plays a critical role in regulating blood pressure, by releasing nitric oxide (NO) and balancing constriction/dilation. Oxidative stress and inflammation damage the endothelium, reducing NO and increasing stiffness.
- Reduced Inflammation
- Ozone therapy (in various forms) has been shown to downregulate inflammatory markers like IL-6, TNF-α in some experimental settings. Ozonated sunflower oil, for example, has demonstrated potent anti-inflammatory effects in lab studies. (MDPI)
- Oil pulling itself, even without ozone, has been shown in some small studies to reduce markers of gingival inflammation; since systemic inflammation often has origins in the mouth (periodontal disease, etc.), improving oral health can have ripple effects.
- Ozone therapy (in various forms) has been shown to downregulate inflammatory markers like IL-6, TNF-α in some experimental settings. Ozonated sunflower oil, for example, has demonstrated potent anti-inflammatory effects in lab studies. (MDPI)
- Lower Oxidative Stress
- Ozone infusions in oils can trap activated oxygen in stable forms (e.g. ozonides, peroxides) which may have antioxidant interactions. In ozonated vegetable oils, there is evidence of antioxidant activity. (PMC)
- Reduced oxidative damage means less damage to lipids (i.e. less LDL oxidation), proteins, DNA, etc., which in turn helps protect blood vessels and heart tissue.
- Ozone infusions in oils can trap activated oxygen in stable forms (e.g. ozonides, peroxides) which may have antioxidant interactions. In ozonated vegetable oils, there is evidence of antioxidant activity. (PMC)
- Better Lipid Profiles (Lower LDL, Higher HDL, Lower Triglycerides)
- Some studies of ozone therapy or ozonated oils have reported improvements in lipids: lowering “bad” cholesterol (LDL, total cholesterol) and triglycerides, increasing HDL. For example, in a study of long-term supplementation of ozonated sunflower oil, lipid lowering effects were observed. (PMC)
- The anti-inflammatory and antioxidant effects also support healthier lipid metabolism, reducing the oxidation of lipids, improving how lipoproteins are handled in the body.
- Some studies of ozone therapy or ozonated oils have reported improvements in lipids: lowering “bad” cholesterol (LDL, total cholesterol) and triglycerides, increasing HDL. For example, in a study of long-term supplementation of ozonated sunflower oil, lipid lowering effects were observed. (PMC)
What the Current Scientific Evidence Shows — and Gaps
While the mechanisms look plausible, it’s important to note what has and has not been proven:
- There are few (if any) clinical trials specifically testing oil pulling with ozonated oil in humans for blood pressure or lipid outcomes. Most of the existing studies are in animals, or in vitro, or using ozonated oils in topical or dietary supplementation forms.
- For example, a 2023 study of long term supplementation of ozonated sunflower oil in diet showed the highest survivability and blood lipid-lowering effect, with potent antioxidant and anti-inflammatory benefits. But that was dietary ingestion / supplementation, not oral swishing. (PMC)
- Another study noted that ozonated sunflower oil had good anti‐inflammatory potential and improved lipid profile (higher HDL, lower LDL, triglycerides) in some settings. (MDPI)
- On blood pressure: natural antioxidants (from plants, diet) more generally have been shown to help endothelial function, reduce oxidative stress, and thereby help with hypertension. But so far I did not find strong published evidence that oil pulling + ozone fixed oil directly reduces blood pressure.
So, while the preliminary data is promising, we can’t yet state with certainty that ozonated oil pulling will definitely lower blood pressure or improve lipids in all people.
How One Might Use Ozonated Oil Pulling as Part of a Cardiovascular-Supportive Routine
If someone is interested, here are considerations and suggestions:
- Use it properly: Swish ~1 teaspoon for 10-15 minutes, then spit out and rinse. Don’t swallow the oil. Consistency may matter (daily or several times per week).
- Oral hygiene matters: Ozonated oil pulling is an adjunct, not a replacement for brushing, flossing, regular dental care. If there’s gum disease or decay, treating those is important.
- Lifestyle synergy: Diet rich in antioxidants, exercise, stress reduction, sleep, good blood sugar control all help — combining ozonated oil pulling with those can produce more robust effects.
- Safety & sourcing: Using high quality, properly produced ozonated oils is crucial. The ozone infusion process must be rigorous so that the product is stable, clean, without unwanted contaminants. PurO3 claims they use ultrapure ozone, certified organic oils, no fillers or synthetic fragrances, and good quality control.
Bottom Line
Oil pulling with ozonated oils is a promising complementary practice that may support cardiovascular health, particularly by helping to reduce inflammation, lower oxidative stress, and improve lipid profiles. There is suggestive evidence in related forms of ozone therapy and in studies of ozonated oils, but direct human clinical trials on outcomes like blood pressure and lipid changes from ozonated oil pulling are limited.
If you’re considering trying it, it may be best viewed as one component in a broader strategy: good nutrition, exercise, stress management, oral hygiene, etc. And as always, anyone with existing cardiovascular disease, high blood pressure, or taking medications should check with a medical professional before making changes.
Buy Pur03 ozonated oil HERE.






