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Statin Drugs: High Risk, Low Reward

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Statin Drugs

In the ever-changing world of cardiology, statin drugs have emerged as a standard solution to a complex problem: combating cardiovascular disease, the global number one killer. 

Originating in the 1980s, these pharmaceuticals were once hailed as the magic bullet in the war against heart disease. The promise was simple—lower cholesterol levels and, in turn, reduce the risk of heart attacks, strokes, and even death. But as with many medical interventions, the realities are not as straightforward as they seem.

Recent research and in-depth analyses reveal that the rewards of statin usage are more illusionary than initially thought. While it’s undeniable that they reduce cholesterol levels, pivotal questions remain. Do we really want to lower cholesterol levels? Do statins genuinely mitigate the overall risk of cardiovascular events to a significant extent? And at what cost to the patient’s overall health?

Beneath the glossy veneer of pharmaceutical endorsements and a multi-billion-dollar industry, we unearth evidence suggesting that many risks overshadow the supposed benefits of statins—some of which can profoundly impact the quality of life. 

Cholesterol – Not the Bad Guy

Few words evoke as much dread as “cholesterol.” As children, we were ingrained with the idea that high cholesterol is a silent killer. “Avoid red meats, embrace oats, drink skim milk, and when all else fails, resort to medication to control those menacing numbers,” we were told. However, the reality of cholesterol is much more nuanced than this black-and-white depiction.

The Real Story of Cholesterol

The very essence of our cells contains cholesterol. Every mammal on Earth, from the great blue whale to your household cat, manufactures cholesterol. This molecule isn’t just a trivial component; it plays a pivotal role in hormone production, vitamin D formation, and digestion. Picture the intricate structure of a cell; its membrane, often referred to as the brain of the cell, is teeming with cholesterol. Moreover, our very own brain, the epicenter of our cognitive function, relies on cholesterol.

But let’s debunk some common myths. Contrary to popular belief:

  • Our bodies autonomously produce cholesterol.
  • Dietary cholesterol has a minimal impact on blood cholesterol levels.
  • Life, as we know it, would be impossible without cholesterol.

As for the age-old dichotomy of LDL being “bad” and HDL being “good” – it’s an oversimplified perspective. Both LDL and HDL serve crucial purposes in our body.

Understanding the Intricacies of Cholesterol Particles

Cholesterol isn’t a solitary entity. Due to its inherent nature, it can’t travel alone in our bloodstream. Imagine oil trying to mix with water; it’s a futile endeavor. Cholesterol requires a vehicle, and that’s where lipoproteins come into play. Acting as transporters, these fat-protein composites, which include LDL, VLDL, HDL, IDL, and chylomicrons, move cholesterol throughout the body.

Notably, not all LDL is identical. These particles vary in size, from minuscule to expansive. Here’s where size truly matters: the smaller LDL particles are problematic, adept at penetrating artery linings. Once embedded, they can oxidize and induce inflammation, endangering the arterial wall’s integrity. In contrast, the larger LDL particles are often benign, seldom causing such damage.

To assess cardiovascular risk effectively, it’s imperative to understand the two primary LDL patterns:

  • LDL – Pattern A: Constituted of larger particles, they are benign unless oxidized.
  • LDL – Pattern B: These smaller, dense particles are the real culprits, prone to lodging in the arterial wall, causing potential harm.

So, while two individuals might have identical LDL-C levels, their risk profiles could be starkly different based on these patterns. Pattern B, for instance, is more indicative of heart-related complications.

The relationship between cholesterol and our health isn’t as straightforward as it’s often portrayed. Rather than focusing solely on lowering cholesterol, it’s crucial to consider the broader picture, including the types and sizes of cholesterol particles. Only then can we genuinely understand and manage the risks associated with cardiovascular health.

High Risk: The Hidden Dangers of Statin Drugs

For years, statins have been hailed as a wonder drug, touted for their cholesterol-lowering capabilities. But beneath the sheen of pharmaceutical advertisements lies a darker story, one where the risks might overshadow the supposed benefits.

Understanding Statin Side Effects

It’s not just about lowering cholesterol. It’s about understanding the ramifications of manipulating our body’s natural processes. Statins, while effective in their primary task, can produce a cascade of side effects, ranging from inconvenient to downright dangerous.

  • Physiological Impacts: At the top of the list are symptoms like low testosterone and the onset of diabetes, ailments that can radically change a person’s quality of life. As cholesterol levels decrease, testosterone levels may also drop since testosterone is derived from cholesterol.
  • Muscle Pain: Nearly three-quarters of statin users have reported muscle pain, with almost a third ceasing medication due to the discomfort. Severe muscle damage, known as rhabdomyolysis, was the reason behind the FDA’s ban on cerivastatin in 2001.
  • Cognitive Impairments: While some research dismisses the connection between statins and dementia, numerous studies highlight brain issues tied to statin use. Some individuals have even experienced transient global amnesia, temporarily losing memory of recent events.
  • Statin Toxicity: Statins can cause inflammation of vital organs like the liver. The risk of neuropathy also skyrockets with extended statin use, becoming 26 times more likely after two years. Heart health ironically is also at stake, with increased risks of heart failure and cardiomyopathy reported in statin users. Studies have found evidence to suggest that statin toxicity is a real thing. 
  • Sleep disturbances: The mental toll of statins is becoming more apparent. Reports detail violent nightmares, mood swings, aggression, and even suicidal tendencies in those taking the drug.

Downplaying the Risks

What makes these revelations even more alarming is the complacency surrounding statin prescriptions. Many individuals on statins mistakenly believe that their cardiovascular health is secure, adopting a laissez-faire approach to diet and lifestyle, falsely comforted by the protective illusion of the pill. This false sense of security is dangerous.

Moreover, statins don’t address the real issue. A lowered LDL-C level does not necessarily equate to reduced heart attack risk, strokes, or death. In essence, statins don’t impact the crucial LDL particle number, meaning many might still face significant cardiac risk despite lowered LDL-C levels from statins.

As we peel back the layers, it becomes apparent that the wide net cast by the statin industry has holes. Over 35 million Americans take a drug with severe risks while failing to deliver the promised protection. The challenge now is to reevaluate, delve deeper into our understanding, and prioritize patient well-being over blind adherence to numbers.

Low Reward: The Marginal (Non-Existent) Benefits of Statin Drugs

While statins are often praised for their cholesterol-lowering properties, the more pertinent question from a patient’s perspective is: “By taking this medication, how significantly will I reduce my risk of a heart attack, stroke, or death?” And herein lies the concern.

Parsing Through the Data

In the realm of medical science, large-scale studies and meta-analyses are gold standards. They allow us to glimpse the broader picture beyond individual experiences. Let’s delve into some key studies to understand the tangible benefits of statin drugs:

General Population Study (2009): A significant meta-analysis, comprising over 70,000 participants, was conducted to assess the impact of statins for primary prevention in individuals with risk factors but no history of heart events or interventions:

  • Annual death rate reduction: 0.1% in statin users compared to placebo.
  • Annual heart attack risk reduction: 0.2% in statin users versus placebo.
  • Annual stroke risk reduction: 0.1% in statin users versus placebo.

JAMA Meta-Analysis (2022): A comprehensive meta-analysis in the renowned Journal of the American Medical Association reinforced these findings, incorporating both primary and secondary prevention groups:

  • Annual mortality reduction: 0.2% in statin users.
  • Annual heart attack risk reduction: 0.3% in statin users.
  • Annual stroke risk reduction: 0.1% in statin users.

Older Population Insights (2017): The benefit of statins takes a sharp turn when we examine older populations. A JAMA study focusing on statin use for primary prevention in individuals over 65 revealed concerning outcomes:

  • Increased death rate: Statin users had an 18% higher death rate than placebo groups.
  • Even higher risks for older seniors: For those above 75, the death rate surged to 34% higher compared to the placebo.

Coronary Calcification Paradox: While many are prescribed statins due to coronary calcification, studies indicate that statins might actually amplify coronary calcification.

Beyond the Numbers

The figures elucidate a crucial insight: the benefits, if any, are marginal. This minimal reward starkly contrasts the alarming risks detailed in the previous section. The coercive narrative from some mainstream cardiologists, suggesting an almost binary choice between taking statins or facing a heart attack, stroke, or death, is simply unsupported by empirical evidence.

The true objective for anyone concerned about cardiovascular health isn’t to trim the risk by minuscule percentages but to substantially diminish it, bringing it as close to zero as feasible. Regrettably, the conventional cardiology approach with statins falls short of this goal. However, achieving this ambitious target is within our reach with the right strategies and interventions.

Next Steps: If Not Statins, Then What?

The revelation about statins’ limited benefits and significant risks might leave many wondering, “If not statins, then what?” The answer lies in addressing the root cause of imbalanced cholesterol levels: inflammation. Rather than merely masking symptoms or forcing a physiological change, the ideal approach should nurture the body back to its natural state of balance.

NHD’s Eat Well, Live Well, Think Well Philosophy

NHD believes that achieving optimal health is a trifecta:

  • Eat Well: Consuming an organic diet rich in anti-inflammatory foods is crucial. Focusing on nutritionally dense foods such as wild fish, grass-fed beef, pasture-raised poultry, and vegetables is best. Avoiding toxic food additives, gluten, processed foods, and GMOs is also imperative. This not only helps regulate cholesterol but also supports overall wellness.
  • Live Well: Regular exercise, ensuring adequate sleep, avoiding toxins, spending time in the sun, and getting chiropractic care profoundly affects cardiovascular health.
  • Think Well: A positive mindset and mental resilience are pivotal in holistic well-being. Your thoughts impact your physiological state, so it’s essential to cultivate a constructive mental environment. Spending time with those you love, reducing stress, and developing a healthy mind go far when managing cholesterol. 

Natural Supplements: A Safer Alternative

For those seeking evidence-based alternatives to pharmaceuticals, numerous natural supplements can address cholesterol imbalances without the associated side effects of medications. One such supplement is OptiLipid, which is specially formulated to support heart health gently and naturally.

Your Health Journey: A Guided Approach

You need not feel cornered if you’re currently on statins or have been advised to start them. NHD offers a complimentary 20-minute health consultation with our expert health coaches. 

These dedicated professionals will attentively listen to your concerns, guide you through the nuances of understanding the root cause through strategic testing, recommend subsequent measures, and assist you in confidently leaving behind the age of statins.

Your health deserves a personalized approach rooted in understanding and nurtured through evidence-based natural interventions. Why settle for less when you can aim for a 100 year heart? 


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He heals the body, instead of just treating the symptoms!

With his professional qualifications as a certified family nurse practitioner, a doctor of chiropractic, and a fellow of the International Academy of Medical Acupuncture, Dr. Smigiel offers patients comprehensive care from a broad perspective of conventional and alternative medicine. He also has extensive experience in functional rehabilitation and chronic pain management.

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Dr. James Kneller is one of the nation’s leading heart rhythm specialists. Dr. Kneller is certified by the American Board of Internal Medicine (ABIM) in Clinical Cardiac Electrophysiology, Cardiovascular Disease, and Internal Medicine.

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About Dr. Lauren Lattanza NMD, FACC

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As a Naturopathic Physician, I am trained to treat the whole person and get to the root cause of disease.

I went to Arizona State University where I graduated with a bachelor’s degree in psychology with a depth in physiology and minor in Spanish. After my undergraduate degree I was working on prerequisite classes towards medical school, which is when I came to learn that my values identified best with the principles of naturopathic medicine. I knew that I wanted to help patients identify the causes of disease and be able to offer treatments which would improve their health rather than simply treating symptoms.

I dedicated the next 4 years to the Southwest College of Naturopathic Medicine in Tempe, Arizona where I attained my Doctorate of Naturopathic Medicine. I served as Class President all 4 years, Board of Trustees – Student Trustee, spoke as the Club President for our branch of Toastmasters, and was voted by my peers and attending physicians to earn the Outstanding Leadership Award for the Class of 2020. Throughout medical school I took it upon myself to work alongside MDs, DOs, chiropractors, and functional medicine practitioners in addition to naturopathic physicians.

As a Spanish speaking student, I was able to volunteer with community clinics around Phoenix and provide free healthcare to low-income families. Due to this combined exposure, I came to find my passion in treating cardiometabolic and digestive disorders that are all too common, yet largely preventable. I took the opportunity to learn the broad spectrum of healthcare so I can ensure that I am able to provide my patients with the best options.

About Dr. Jack Wolfson DO, FACC

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Dr. Jack Wolfson is a board-certified cardiologist, Amazon best-selling author, husband, father, and the nation’s #1 Natural Heart Doctor.

For more than two decades, more than one million people have enjoyed the warmth, compassion, and transformational power of his natural heart health courses and events.

Dr. Wolfson is the founder of Natural Heart Doctor Scottsdale, his heart health practice in Arizona, and Natural Heart Doctor, an online resource center with natural health information. Doctors from across the globe reach out to Dr. Wolfson for training and education in holistic health practices.

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Our chiropractor is an expert at adjustments and holistic chiropractic care and works closely in conjunction with the other health care experts at Natural Heart Doctor.

Call (480) 535-6844 for details and scheduling.

IV Therapy

We use specially formulated natural vitamins and minerals that are injected into a vein to prevent or treat dehydration. Ideal for people in Arizona.

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Stimulate your body’s natural healing abilities and promote physical and emotional well-being with acupuncture at Natural Heart Doctor.

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Health Coaching

Our health coaches use evidence based skillful conversation, clinical interventions, and strategies to engage you actively and safely in health behavior changes.

Call (480) 535-6844 for details and scheduling.

Cardio Tests

We use the most advanced testing in the world to assess heart health and to identify the root cause of your health issues.

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Office Visits

Schedule an office visit with one of our cardiologists, holistic physicians, chiropractor, or health coaches.

Call (480) 535-6844 for details and scheduling.

Frequently Asked Questions

I’d like to receive an online second opinion from Natural Heart Doctor. What do I do next?

You can initiate a second opinion online through our website at any time. To begin, select the team member you’d like to speak with and open an account.

Click here for cardiologist Dr. Jack Wolfson.

Naturopathic Medical Doctor Dr. Lauren Lattanza. Get details.

Naturopathic Medical Doctor Dr. Tonia Rainier. Get details.

Click here for  Natural Heart Doctor Health Coach.

Alternatively, you can email health@naturalheartdoctor.com. A member of our care team will help guide you through the process of starting a second opinion.

What is the cost of a Natural Heart Doctor Online Second Opinion?

The cost for most second opinions varies by team member. This fee includes information collection, a phone or video consultation, a second opinion from a Natural Heart Doctor specialist and guidance throughout the process from your personal Care Team at Natural Heart Doctor.

Cardiologist Dr. Jack Wolfson’s Second Opinion Fee is $1500.

Holistic Physician’s Dr. Lauren Lattanza’s Second Opinion Fee is $250.

Naturopathic Physician Dr. Tonia Rainier’s Second Opinion Fee is $250.

Note: We apply the Online Second Opinion Call fee as a credit to any future consultations with Natural Heart Doctor, should you choose them.

Will my insurance cover the cost of a Natural Heart Doctor Online Second Opinion?

Most likely, no. Most health plans do not cover online second opinions or consultations. You are responsible for the cost of our second opinion. Natural Heart Doctor cannot file a claim with your insurance carrier, nor can we provide a procedure (CPT) code for this service.

What is the timeline to receive an online second opinion?

We do our best to schedule your second opinion as quickly as possible. Typically, it takes 5 to 7 business days after your information has been collected to receive your phone or video online second opinion.

What information do you need in advance of our call?

Our office will send you a short questionnaire to complete and return. We DO NOT need your complete medical records.

How many questions can I ask the expert during our call?

You may ask a maximum of five questions. This is to ensure that the expert has sufficient time to devote to each question. All questions must be finalized before your online meeting.

What should I expect to receive once my second opinion is complete?

You will receive a summary of our discussion along with our second opinion. The second opinion will be in written form. After you have reviewed the second opinion, a Natural Heart Doctor clinician will follow up with you by phone to address general medical questions about the information provided in the second opinion.

What if I have follow-up questions for the expert after I have reviewed my second opinion?

If you have a clarifying question about an expert’s response to one of the questions in your second opinion, and the Natural Heart Doctor clinician is unable to address it, then you may request a follow up session for an additional fee. 

Is my medical and payment information secure?

Natural Heart Doctor is strongly committed to protecting the privacy and security of all our patients. Our website meets all federal requirements for protecting personal health information under the Health Insurance Portability and Accountability Act (HIPAA). All financial transactions are processed by Natural Heart Doctor securely using industry standard payment processing tools.

I would rather visit Natural Heart Doctor for an in-person appointment. What should I do next?

If you would prefer an in-person appointment at Natural Heart Doctor instead of an online second opinion, please call (480) 535-6844 for details and scheduling.

Can I schedule a follow up appointment with the specialist who provided my online second opinion?

Yes, we’re happy to help you on an extended basis. Our clinician can discuss options with you when presenting our second opinion summary.