High blood pressure, or hypertension, has a genetic component, and several genetic markers have been associated with increased susceptibility. While your genes may load the gun, violations of the 100 Year Heart Method pull the triggers. So, don’t violate the method!

You can’t change your DNA, but you CAN change everything else. 

Key genetic markers include:

1. AGT (Angiotensinogen Gene): Variants in the AGT gene, particularly the M235T polymorphism, are linked to an increased risk of hypertension. AGT plays a role in blood pressure regulation by influencing angiotensin production, which impacts blood vessel constriction.

2. ACE (Angiotensin-Converting Enzyme Gene): The ACE gene, particularly the I/D polymorphism, affects angiotensin II production, a potent vasoconstrictor. Variants associated with increased ACE levels can elevate blood pressure by promoting vascular constriction and sodium retention.

3. ADD1 (Alpha-Adducin Gene): Variants in ADD1, like the Gly460Trp polymorphism, can increase sodium reabsorption in the kidneys, leading to higher blood pressure levels. ADD1 helps regulate ion transport and vascular tone.

4. CYP11B2 (Aldosterone Synthase Gene): The CYP11B2 gene is involved in aldosterone production, a hormone that regulates salt and water balance. The T344C polymorphism in CYP11B2 has been associated with elevated aldosterone levels and hypertension.

5. NOS3 (Endothelial Nitric Oxide Synthase Gene): NOS3 variants, particularly the Glu298Asp polymorphism, can impair nitric oxide production, leading to reduced vasodilation and increased blood pressure.

6. GNB3 (G Protein Subunit Beta 3 Gene): The C825T polymorphism in GNB3 has been linked to hypertension, particularly in individuals with salt-sensitive high blood pressure. This gene affects signal transduction in vascular and renal systems.

7. SLC4A5 (Sodium Bicarbonate Cotransporter Gene): Variants in SLC4A5 can affect sodium reabsorption in the kidneys, contributing to salt-sensitive hypertension.

8. KCNJ1 (Potassium Channel, Inwardly Rectifying Subfamily J, Member 1): KCNJ1 polymorphisms can disrupt potassium handling, affecting blood pressure regulation.

If you don’t have the “best” genetics, or even if you do, work with us to get the care you need and the life of your dreams.