The Gut–Heart Connection: Why Short-Chain Fatty Acids Are A Missing Link in Cardiovascular Health

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The Gut–Heart Connection

When most people think about heart health, they focus on cholesterol, blood pressure, or inflammation. But what if one of the most powerful indicators of cardiovascular wellness comes not from your arteries—but from your gut?

Inside your digestive tract, trillions of microbes work around the clock to protect you. When these beneficial bacteria ferment plant fibers and resistant starches, they produce small but mighty molecules called short-chain fatty acids (SCFAs). These include acetate, propionate, and butyrate—the true metabolic messengers of a healthy gut and a healthy heart.

Modern testing, such as a stool SCFA test, measures these compounds and provides a window into the balance of your gut microbiome. Low levels are an early warning sign that your gut barrier, immune system, and even your cardiovascular system may be under strain.


🔬 What the Stool SCFA Test Measures

This test analyzes the three major SCFAs—acetate, propionate, and butyrate—produced by your gut bacteria. Together, these compounds:

  • Strengthen the intestinal lining and prevent “leaky gut”
  • Regulate inflammation and immune balance
  • Support healthy lipid metabolism
  • Influence blood pressure and vascular tone
  • Communicate with your brain, liver, and heart through the gut–heart axis

Test Your Gut Health HERE.


❤️ How Low SCFAs Impact Cardiovascular Health

Low levels of SCFAs signal an unhealthy gut ecosystem—and research now shows this directly affects heart function.

  • Leaky Gut & Inflammation: Without adequate butyrate, the intestinal barrier becomes porous, allowing bacterial toxins (like lipopolysaccharides) to enter the bloodstream. These toxins trigger inflammation and damage the vascular lining.
  • Abnormal Lipids: SCFAs improve the way your body handles fats, lowering triglycerides and optimizing HDL function.
  • Blood Pressure Dysregulation: Propionate and acetate interact with receptors on blood vessel walls to maintain healthy vascular tone and nitric oxide production.
  • Oxidative Stress: When butyrate and propionate levels drop, antioxidant defenses weaken, leading to oxidative injury and endothelial dysfunction—the early stage of heart disease.

In short, low SCFAs create a pro-inflammatory, pro-atherogenic environment that sets the stage for cardiovascular disease.


⚠️ What Causes Low SCFA Levels

Several lifestyle factors deplete these protective compounds:

  • Low-fiber, low-vegetable diets
  • Processed foods and seed oils
  • Antibiotic use or gut infections
  • Poor sleep, stress, and sedentary habits
  • Lack of environmental and microbial exposure
  • Reduced bile flow or poor digestion

🌿 How to Raise SCFA Levels Naturally

1. Eat fiber-rich, whole foods:
Root vegetables, cooked and cooled potatoes or rice (resistant starch), onions, garlic, leeks, Jerusalem artichokes, green bananas, berries, and cruciferous vegetables all nourish SCFA-producing microbes.

2. Add fermented foods:
Sauerkraut, kimchi, kefir, and raw yogurt deliver live bacteria that support healthy fermentation.

3. Choose polyphenol-rich foods:
Olive oil, pomegranate, cacao, and berries enhance the growth of beneficial gut species.

4. Spend time outdoors:
Exposure to soil and animals expands microbial diversity.

5. Support healthy digestion:
Adequate bile flow, enzymes, and stomach acid optimize nutrient absorption and microbial balance.


💊 Supplement Support for the Gut–Heart Axis

At Natural Heart Doctor, we often recommend targeted support to restore gut integrity and boost SCFA levels:

  • Sodium Butyrate: Supplies direct butyrate to the gut lining, strengthening the barrier and lowering systemic inflammation.
  • BodyBio PC (Phosphatidylcholine): Restores healthy cell membranes and bile composition, creating the right environment for beneficial microbes to thrive.
  • Emu Oil: Rich in omega-3 fats and vitamin K2 (MK-4), it supports endothelial health, vascular flexibility, and anti-inflammatory pathways.
  • Wild Salmon Roe: A potent source of phospholipid-bound DHA and astaxanthin to reduce oxidative stress and support the gut–brain–heart connection.

Together, these nutrients help repair the gut barrier, rebalance the microbiome, and protect your cardiovascular system from the inside out.


Test, Don’t Guess- When it comes to gut health, get tested. Click HERE for our recommended test panel. 

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About Dr. Keith Smigiel NP, DC

Dr. Keith Smigiel

Dr. Keith Smigiel is a regenerative medicine physician and pain management specialist. He takes an integrative approach to medicine, focusing on customized solutions tailored to individual needs. Using advanced, non-surgical treatments, Dr. Smigiel stimulates your body’s ability to naturally heal itself.

Dr. Smigiel helps people suffering from conditions such as chronic pain and erectile dysfunction, to hair loss and weight gain. Combining treatments such as PRP Therapy, Ozone, Neural Prolotherapy, and IV Infusions with functional rehabilitation, he helps you look and feel better.

He heals the body, instead of just treating the symptoms!

With his professional qualifications as a certified family nurse practitioner, a doctor of chiropractic, and a fellow of the International Academy of Medical Acupuncture, Dr. Smigiel offers patients comprehensive care from a broad perspective of conventional and alternative medicine. He also has extensive experience in functional rehabilitation and chronic pain management.

Dr. Smigiel is married to Angela and has two children, Sophia and Larz. When he’s not busy helping patients, he enjoys hiking, mountain biking, motocross, and boating.

About Dr. Lauren Lattanza NMD, FACC

Dr. Lattanza Office Visit with Patient

As a Naturopathic Physician, I am trained to treat the whole person and get to the root cause of disease.

I went to Arizona State University where I graduated with a bachelor’s degree in psychology with a depth in physiology and minor in Spanish. After my undergraduate degree I was working on prerequisite classes towards medical school, which is when I came to learn that my values identified best with the principles of naturopathic medicine. I knew that I wanted to help patients identify the causes of disease and be able to offer treatments which would improve their health rather than simply treating symptoms.

I dedicated the next 4 years to the Southwest College of Naturopathic Medicine in Tempe, Arizona where I attained my Doctorate of Naturopathic Medicine. I served as Class President all 4 years, Board of Trustees – Student Trustee, spoke as the Club President for our branch of Toastmasters, and was voted by my peers and attending physicians to earn the Outstanding Leadership Award for the Class of 2020. Throughout medical school I took it upon myself to work alongside MDs, DOs, chiropractors, and functional medicine practitioners in addition to naturopathic physicians.

As a Spanish speaking student, I was able to volunteer with community clinics around Phoenix and provide free healthcare to low-income families. Due to this combined exposure, I came to find my passion in treating cardiometabolic and digestive disorders that are all too common, yet largely preventable. I took the opportunity to learn the broad spectrum of healthcare so I can ensure that I am able to provide my patients with the best options.

About Dr. Jack Wolfson DO, FACC

Dr. Wolfson Office Visit with Patient

Dr. Jack Wolfson is a cardiologist, Amazon best-selling author, husband, father, and the nation’s #1 Natural Heart Doctor.

For more than two decades, more than one million people have enjoyed the warmth, compassion, and transformational power of his natural heart health courses and events.

Dr. Wolfson is the founder of Natural Heart Doctor Scottsdale, his heart health practice in Arizona, and Natural Heart Doctor, an online resource center with natural health information. Doctors from across the globe reach out to Dr. Wolfson for training and education in holistic health practices.

He has been named one of America’s Top Functional Medicine Doctors and is a five-time winner of the Natural Choice Awards as a holistic M.D. Dr. Wolfson’s work has been covered by more than 100 media outlets, including NBC, CNN, and the Washington Post. His book “The Paleo Cardiologist: The Natural Way to Heart Health” was an Amazon #1 best-seller.

Dr. Wolfson and his wife Heather have four children and are committed to making the world a better place to live. They provide for those in need (including animals) and support natural health causes through their philanthropic efforts.

Chiropractic

Our chiropractor is an expert at adjustments and holistic chiropractic care and works closely in conjunction with the other health care experts at Natural Heart Doctor.

Call (480) 535-6844 for details and scheduling.

IV Therapy

We use specially formulated natural vitamins and minerals that are injected into a vein to prevent or treat dehydration. Ideal for people in Arizona.

Call (480) 535-6844 for details and scheduling.

Acupuncture

Stimulate your body’s natural healing abilities and promote physical and emotional well-being with acupuncture at Natural Heart Doctor.

Call (480) 535-6844 for details and scheduling.

Health Coaching

Our health coaches use evidence based skillful conversation, clinical interventions, and strategies to engage you actively and safely in health behavior changes.

Call (480) 535-6844 for details and scheduling.

Cardio Tests

We use the most advanced testing in the world to assess heart health and to identify the root cause of your health issues.

Call (480) 535-6844 for details and scheduling.

Office Visits

Schedule an office visit with one of our cardiologists, holistic physicians, chiropractor, or health coaches.

Call (480) 535-6844 for details and scheduling.

Frequently Asked Questions

I’d like to receive an online second opinion from Natural Heart Doctor. What do I do next?

You can initiate a second opinion online through our website at any time. To begin, select the team member you’d like to speak with and open an account.

Click here for cardiologist Dr. Jack Wolfson.

Naturopathic Medical Doctor Dr. Lauren Lattanza. Get details.

Naturopathic Medical Doctor Dr. Tonia Rainier. Get details.

Click here for  Natural Heart Doctor Health Coach.

Alternatively, you can email health@naturalheartdoctor.com. A member of our care team will help guide you through the process of starting a second opinion.

What is the cost of a Natural Heart Doctor Online Second Opinion?

The cost for most second opinions varies by team member. This fee includes information collection, a phone or video consultation, a second opinion from a Natural Heart Doctor specialist and guidance throughout the process from your personal Care Team at Natural Heart Doctor.

Cardiologist Dr. Jack Wolfson’s Second Opinion Fee is $1500.

Holistic Physician’s Dr. Lauren Lattanza’s Second Opinion Fee is $250.

Naturopathic Physician Dr. Tonia Rainier’s Second Opinion Fee is $250.

Note: We apply the Online Second Opinion Call fee as a credit to any future consultations with Natural Heart Doctor, should you choose them.

Will my insurance cover the cost of a Natural Heart Doctor Online Second Opinion?

Most likely, no. Most health plans do not cover online second opinions or consultations. You are responsible for the cost of our second opinion. Natural Heart Doctor cannot file a claim with your insurance carrier, nor can we provide a procedure (CPT) code for this service.

What is the timeline to receive an online second opinion?

We do our best to schedule your second opinion as quickly as possible. Typically, it takes 5 to 7 business days after your information has been collected to receive your phone or video online second opinion.

What information do you need in advance of our call?

Our office will send you a short questionnaire to complete and return. We DO NOT need your complete medical records.

How many questions can I ask the expert during our call?

You may ask a maximum of five questions. This is to ensure that the expert has sufficient time to devote to each question. All questions must be finalized before your online meeting.

What should I expect to receive once my second opinion is complete?

You will receive a summary of our discussion along with our second opinion. The second opinion will be in written form. After you have reviewed the second opinion, a Natural Heart Doctor clinician will follow up with you by phone to address general medical questions about the information provided in the second opinion.

What if I have follow-up questions for the expert after I have reviewed my second opinion?

If you have a clarifying question about an expert’s response to one of the questions in your second opinion, and the Natural Heart Doctor clinician is unable to address it, then you may request a follow up session for an additional fee. 

Is my medical and payment information secure?

Natural Heart Doctor is strongly committed to protecting the privacy and security of all our patients. Our website meets all federal requirements for protecting personal health information under the Health Insurance Portability and Accountability Act (HIPAA). All financial transactions are processed by Natural Heart Doctor securely using industry standard payment processing tools.

I would rather visit Natural Heart Doctor for an in-person appointment. What should I do next?

If you would prefer an in-person appointment at Natural Heart Doctor instead of an online second opinion, please call (480) 535-6844 for details and scheduling.

Can I schedule a follow up appointment with the specialist who provided my online second opinion?

Yes, we’re happy to help you on an extended basis. Our clinician can discuss options with you when presenting our second opinion summary.