Why Humans Can’t Make Vitamin C and Why Your Heart Depends On It

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Citrus fruits heart shape

Most animals produce their own vitamin C.

Humans do not.

And that single biological difference may be one of the most overlooked drivers of cardiovascular vulnerability in modern life.

The Missing Enzyme That Changes Everything

The GULO gene

Humans carry the genetic code for producing vitamin C, but the gene is broken.

The GULO gene, responsible for making the enzyme needed to produce vitamin C, is inactive in humans. It is not “turned off” in a reversible way. It is damaged and nonfunctional.

This means:

  • Your body cannot produce vitamin C
  • You cannot increase production during stress
  • You are 100 percent dependent on external sources

Compare that to animals like goats, who can produce thousands of milligrams per day and dramatically increase production during illness or stress.

Humans cannot.

Why This Matters for Your Heart

Vitamin C is not just another nutrient. It is foundational to cardiovascular structure and function.

1. Collagen Production and Arterial Integrity

Vitamin C is essential for collagen synthesis.

Collagen is what gives your blood vessels strength, elasticity, and resilience. Without adequate vitamin C:

  • Arterial walls weaken
  • Micro-injuries develop
  • Repair mechanisms are compromised

This creates the perfect environment for vascular dysfunction.

2. Protection Against Oxidative Stress

Oxidative stress is one of the primary drivers of cardiovascular disease.

Vitamin C is one of the body’s most important antioxidants, helping to:

  • Neutralize free radicals
  • Reduce lipid peroxidation
  • Protect the endothelium

When oxidative stress overwhelms your defenses, damage accumulates in the arteries.

3. Nitric Oxide and Blood Flow

Vitamin C plays a key role in maintaining nitric oxide availability.

This supports:

  • Healthy vasodilation
  • Optimal blood pressure
  • Efficient circulation

Without enough vitamin C, nitric oxide signaling suffers.

You Cannot “Activate” Vitamin C Production

AI image of woman trying to repair a DNA strand

There is no supplement, diet, detox, or biohack that can turn the GULO gene back on.

This is not an epigenetic issue.

It is a structural genetic defect.

So the question is not how to activate vitamin C production.

The question is:

Are you getting enough to meet your daily needs in a world full of oxidative stress?

Best Whole Food Sources of Vitamin C

The goal is consistent intake from real, nutrient-dense sources.

Animal-Based Sources

While not typically thought of as high in vitamin C, properly sourced animal foods can contribute:

Kickstart My Heart Elk Organs
Contains small but meaningful amounts of naturally occurring vitamin C, particularly from liver and adrenal tissue, typically in the range of approximately 5 to 15 mg per serving depending on sourcing and batch

Wild Salmon Roe
Provides trace amounts of vitamin C along with powerful fat-soluble nutrients and antioxidants, typically around 1 to 3 mg per serving

These foods also provide synergistic nutrients like copper, retinol, and B vitamins that support collagen and vascular health.

Plant-Based Sources

Some of the richest natural sources include:

Camu camu (up to 700 mg per teaspoon powder)
Acerola cherry (300 to 1600 mg per 100 grams)
Guava (200 mg per fruit)
Kiwi (70 to 90 mg per fruit)
Red bell peppers (150 to 200 mg per cup)
Strawberries (80 to 100 mg per cup)
Citrus fruits (50 to 70 mg per serving)

Why Food Alone May Not Be Enough

Sources of Vitamin C - oranges, strawberries, red and green capsicum peppers, dark leafy green, parsley, broccoli

In an ideal world, food would meet all your needs.

But today’s reality includes:

  • Environmental toxins
  • Chronic inflammation
  • Poor soil quality
  • Increased oxidative stress
  • Higher metabolic demand

All of these increase your requirement for vitamin C.

And remember, unlike animals, you cannot make more when demand increases.

The Strategic Role of Supplementation

Artistic shot of vitamin C orange tablet  dissolving

This is where targeted supplementation becomes essential.

A high-quality vitamin C supplement can:

  • Support collagen formation
  • Enhance antioxidant defenses
  • Promote vascular integrity
  • Help maintain healthy blood pressure

Why We Recommend Super C

Super C Vitamin C Supplement

Super C is designed to deliver powerful, bioavailable vitamin C in a form your body can actually use.

It complements a nutrient-dense diet and helps bridge the gap created by modern stressors.

For those serious about protecting their heart, this is not optional.

It is foundational.

Buy Super C HERE. 

Final Thought

Most animals make their own vitamin C.

Humans lost that ability.

Now look at the explosion of cardiovascular disease.

This is not a coincidence.

Your body depends on vitamin C every single day for structural integrity, antioxidant protection, and optimal blood flow.

The only question is whether you are giving it enough.

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About Dr. Keith Smigiel NP, DC

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Dr. Keith Smigiel is a regenerative medicine physician and pain management specialist. He takes an integrative approach to medicine, focusing on customized solutions tailored to individual needs. Using advanced, non-surgical treatments, Dr. Smigiel stimulates your body’s ability to naturally heal itself.

Dr. Smigiel helps people suffering from conditions such as chronic pain and erectile dysfunction, to hair loss and weight gain. Combining treatments such as PRP Therapy, Ozone, Neural Prolotherapy, and IV Infusions with functional rehabilitation, he helps you look and feel better.

He heals the body, instead of just treating the symptoms!

With his professional qualifications as a certified family nurse practitioner, a doctor of chiropractic, and a fellow of the International Academy of Medical Acupuncture, Dr. Smigiel offers patients comprehensive care from a broad perspective of conventional and alternative medicine. He also has extensive experience in functional rehabilitation and chronic pain management.

Dr. Smigiel is married to Angela and has two children, Sophia and Larz. When he’s not busy helping patients, he enjoys hiking, mountain biking, motocross, and boating.

About Dr. Lauren Lattanza NMD, FACC

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As a Naturopathic Physician, I am trained to treat the whole person and get to the root cause of disease.

I went to Arizona State University where I graduated with a bachelor’s degree in psychology with a depth in physiology and minor in Spanish. After my undergraduate degree I was working on prerequisite classes towards medical school, which is when I came to learn that my values identified best with the principles of naturopathic medicine. I knew that I wanted to help patients identify the causes of disease and be able to offer treatments which would improve their health rather than simply treating symptoms.

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As a Spanish speaking student, I was able to volunteer with community clinics around Phoenix and provide free healthcare to low-income families. Due to this combined exposure, I came to find my passion in treating cardiometabolic and digestive disorders that are all too common, yet largely preventable. I took the opportunity to learn the broad spectrum of healthcare so I can ensure that I am able to provide my patients with the best options.

About Dr. Jack Wolfson DO, FACC

Dr. Wolfson Office Visit with Patient

Dr. Jack Wolfson is a cardiologist, Amazon best-selling author, husband, father, and the nation’s #1 Natural Heart Doctor.

For more than two decades, more than one million people have enjoyed the warmth, compassion, and transformational power of his natural heart health courses and events.

Dr. Wolfson is the founder of Natural Heart Doctor Scottsdale, his heart health practice in Arizona, and Natural Heart Doctor, an online resource center with natural health information. Doctors from across the globe reach out to Dr. Wolfson for training and education in holistic health practices.

He has been named one of America’s Top Functional Medicine Doctors and is a five-time winner of the Natural Choice Awards as a holistic M.D. Dr. Wolfson’s work has been covered by more than 100 media outlets, including NBC, CNN, and the Washington Post. His book “The Paleo Cardiologist: The Natural Way to Heart Health” was an Amazon #1 best-seller.

Dr. Wolfson and his wife Heather have four children and are committed to making the world a better place to live. They provide for those in need (including animals) and support natural health causes through their philanthropic efforts.

Chiropractic

Our chiropractor is an expert at adjustments and holistic chiropractic care and works closely in conjunction with the other health care experts at Natural Heart Doctor.

Call (480) 535-6844 for details and scheduling.

IV Therapy

We use specially formulated natural vitamins and minerals that are injected into a vein to prevent or treat dehydration. Ideal for people in Arizona.

Call (480) 535-6844 for details and scheduling.

Acupuncture

Stimulate your body’s natural healing abilities and promote physical and emotional well-being with acupuncture at Natural Heart Doctor.

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Health Coaching

Our health coaches use evidence based skillful conversation, clinical interventions, and strategies to engage you actively and safely in health behavior changes.

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Cardio Tests

We use the most advanced testing in the world to assess heart health and to identify the root cause of your health issues.

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Office Visits

Schedule an office visit with one of our cardiologists, holistic physicians, chiropractor, or health coaches.

Call (480) 535-6844 for details and scheduling.

Frequently Asked Questions

I’d like to receive an online second opinion from Natural Heart Doctor. What do I do next?

You can initiate a second opinion online through our website at any time. To begin, select the team member you’d like to speak with and open an account.

Click here for cardiologist Dr. Jack Wolfson.

Naturopathic Medical Doctor Dr. Lauren Lattanza. Get details.

Naturopathic Medical Doctor Dr. Tonia Rainier. Get details.

Click here for  Natural Heart Doctor Health Coach.

Alternatively, you can email health@naturalheartdoctor.com. A member of our care team will help guide you through the process of starting a second opinion.

What is the cost of a Natural Heart Doctor Online Second Opinion?

The cost for most second opinions varies by team member. This fee includes information collection, a phone or video consultation, a second opinion from a Natural Heart Doctor specialist and guidance throughout the process from your personal Care Team at Natural Heart Doctor.

Cardiologist Dr. Jack Wolfson’s Second Opinion Fee is $1500.

Holistic Physician’s Dr. Lauren Lattanza’s Second Opinion Fee is $250.

Naturopathic Physician Dr. Tonia Rainier’s Second Opinion Fee is $250.

Note: We apply the Online Second Opinion Call fee as a credit to any future consultations with Natural Heart Doctor, should you choose them.

Will my insurance cover the cost of a Natural Heart Doctor Online Second Opinion?

Most likely, no. Most health plans do not cover online second opinions or consultations. You are responsible for the cost of our second opinion. Natural Heart Doctor cannot file a claim with your insurance carrier, nor can we provide a procedure (CPT) code for this service.

What is the timeline to receive an online second opinion?

We do our best to schedule your second opinion as quickly as possible. Typically, it takes 5 to 7 business days after your information has been collected to receive your phone or video online second opinion.

What information do you need in advance of our call?

Our office will send you a short questionnaire to complete and return. We DO NOT need your complete medical records.

How many questions can I ask the expert during our call?

You may ask a maximum of five questions. This is to ensure that the expert has sufficient time to devote to each question. All questions must be finalized before your online meeting.

What should I expect to receive once my second opinion is complete?

You will receive a summary of our discussion along with our second opinion. The second opinion will be in written form. After you have reviewed the second opinion, a Natural Heart Doctor clinician will follow up with you by phone to address general medical questions about the information provided in the second opinion.

What if I have follow-up questions for the expert after I have reviewed my second opinion?

If you have a clarifying question about an expert’s response to one of the questions in your second opinion, and the Natural Heart Doctor clinician is unable to address it, then you may request a follow up session for an additional fee. 

Is my medical and payment information secure?

Natural Heart Doctor is strongly committed to protecting the privacy and security of all our patients. Our website meets all federal requirements for protecting personal health information under the Health Insurance Portability and Accountability Act (HIPAA). All financial transactions are processed by Natural Heart Doctor securely using industry standard payment processing tools.

I would rather visit Natural Heart Doctor for an in-person appointment. What should I do next?

If you would prefer an in-person appointment at Natural Heart Doctor instead of an online second opinion, please call (480) 535-6844 for details and scheduling.

Can I schedule a follow up appointment with the specialist who provided my online second opinion?

Yes, we’re happy to help you on an extended basis. Our clinician can discuss options with you when presenting our second opinion summary.