Why Lab-Made Folic Acid (and Folate) Can’t Compete with Real Food

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Lab-Made Folic Acid

For decades, health authorities have told us to take folic acid for heart health, pregnancy, and longevity. Supplement companies now push methylated folate (5-MTHF) as the “active” form your body needs. But here’s the truth: both folic acid and lab-made folate are no match for the real thing — natural folate from food.

Folic Acid: An Unnatural Shortcut

Folic acid is a synthetic invention. It doesn’t exist in nature. Once swallowed, your body must convert it into usable forms through multiple enzyme steps. Many people, especially those with MTHFR gene variations, can’t efficiently do this.

The result? Unmetabolized folic acid circulating in your blood — a foreign substance the body never evolved to handle.

Lab-Made Folate: Still Missing the Mark

Marketers tried to improve on folic acid by selling 5-MTHF (5-methyltetrahydrofolate). While this is closer to what your body uses, it’s still a man-made isolate.

Here’s the problem: 5-MTHF is just one of the five natural folate forms your body needs.

  • Tetrahydrofolate (THF): the core reduced form.
  • 5-MTHF: the main circulating form in blood.
  • 5-formyl-THF (folinic acid): a storage form, also used therapeutically.
  • 10-formyl-THF: essential for purine (DNA/RNA) synthesis.
  • 5,10-methylene-THF: required for thymidylate synthesis (DNA production).

When you take a pill of lab-made 5-MTHF, you’re getting only a fraction of what real food delivers.

Food: Where Folate Belongs

Nature doesn’t deliver nutrients in isolation. Real foods contain a full spectrum of folate forms, combined with cofactors like vitamin B12, choline, minerals, and antioxidants that work together to optimize absorption and function.

  • Organs: Bison organs like liver, heart, and kidney are loaded with the perfect forms of all the natural folates, plus B12 and other methyl donors critical for heart and brain health.
  • Wild Salmon Roe: A rich source of natural folates paired with DHA, phospholipids, and antioxidants to support fertility, cognition, and cardiovascular vitality.
  • Leafy greens, asparagus, avocado: Plant-based folates in their natural biochemical family.

This synergy is impossible to replicate in a laboratory.

Why Natural Heart Doctor Supplements Are Different

At Natural Heart Doctor, we believe supplements should be food, not chemistry experiments. That’s why we offer two of the most powerful, natural folate-rich foods on the planet:

  • Kickstart My Heart — a bison organ complex sourced from unvaccinated, prairie grass-fed, field-harvested bison. Each capsule contains a blend of liver, heart, and kidney — the most concentrated natural sources of folate and B12 on Earth. Unlike folic acid or lab-made folate, these nutrients come exactly as nature intended, in all their natural forms, in perfect balance.
  • Wild Salmon Roe — nature’s superfood for the heart, brain, and reproductive system. Wild roe delivers folate along with omega-3s, phospholipids, and antioxidants in a package no lab can mimic.

No synthetic isolates. No fake vitamins. Just the ancestral foods your body recognizes and thrives on.

The Bottom Line

Folic acid is cheap and unnatural. Lab-made 5-MTHF is just one slice of a much bigger picture. Only real food provides the full family of folates in harmony with nature’s design.

If you want to truly support your heart, brain, fertility, and longevity, ditch the synthetic shortcuts and fuel your body with what it was designed to eat.

👉 Kickstart My Heart Bison Organ Complex and Wild Salmon Roe — the purest, most powerful way to restore real folate to your diet and reclaim your ancestral nutrition.

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About Dr. Keith Smigiel NP, DC

Dr. Keith Smigiel

Dr. Keith Smigiel is a regenerative medicine physician and pain management specialist. He takes an integrative approach to medicine, focusing on customized solutions tailored to individual needs. Using advanced, non-surgical treatments, Dr. Smigiel stimulates your body’s ability to naturally heal itself.

Dr. Smigiel helps people suffering from conditions such as chronic pain and erectile dysfunction, to hair loss and weight gain. Combining treatments such as PRP Therapy, Ozone, Neural Prolotherapy, and IV Infusions with functional rehabilitation, he helps you look and feel better.

He heals the body, instead of just treating the symptoms!

With his professional qualifications as a certified family nurse practitioner, a doctor of chiropractic, and a fellow of the International Academy of Medical Acupuncture, Dr. Smigiel offers patients comprehensive care from a broad perspective of conventional and alternative medicine. He also has extensive experience in functional rehabilitation and chronic pain management.

Dr. Smigiel is married to Angela and has two children, Sophia and Larz. When he’s not busy helping patients, he enjoys hiking, mountain biking, motocross, and boating.

About Dr. Lauren Lattanza NMD, FACC

Dr. Lattanza Office Visit with Patient

As a Naturopathic Physician, I am trained to treat the whole person and get to the root cause of disease.

I went to Arizona State University where I graduated with a bachelor’s degree in psychology with a depth in physiology and minor in Spanish. After my undergraduate degree I was working on prerequisite classes towards medical school, which is when I came to learn that my values identified best with the principles of naturopathic medicine. I knew that I wanted to help patients identify the causes of disease and be able to offer treatments which would improve their health rather than simply treating symptoms.

I dedicated the next 4 years to the Southwest College of Naturopathic Medicine in Tempe, Arizona where I attained my Doctorate of Naturopathic Medicine. I served as Class President all 4 years, Board of Trustees – Student Trustee, spoke as the Club President for our branch of Toastmasters, and was voted by my peers and attending physicians to earn the Outstanding Leadership Award for the Class of 2020. Throughout medical school I took it upon myself to work alongside MDs, DOs, chiropractors, and functional medicine practitioners in addition to naturopathic physicians.

As a Spanish speaking student, I was able to volunteer with community clinics around Phoenix and provide free healthcare to low-income families. Due to this combined exposure, I came to find my passion in treating cardiometabolic and digestive disorders that are all too common, yet largely preventable. I took the opportunity to learn the broad spectrum of healthcare so I can ensure that I am able to provide my patients with the best options.

About Dr. Jack Wolfson DO, FACC

Dr. Wolfson Office Visit with Patient

Dr. Jack Wolfson is a cardiologist, Amazon best-selling author, husband, father, and the nation’s #1 Natural Heart Doctor.

For more than two decades, more than one million people have enjoyed the warmth, compassion, and transformational power of his natural heart health courses and events.

Dr. Wolfson is the founder of Natural Heart Doctor Scottsdale, his heart health practice in Arizona, and Natural Heart Doctor, an online resource center with natural health information. Doctors from across the globe reach out to Dr. Wolfson for training and education in holistic health practices.

He has been named one of America’s Top Functional Medicine Doctors and is a five-time winner of the Natural Choice Awards as a holistic M.D. Dr. Wolfson’s work has been covered by more than 100 media outlets, including NBC, CNN, and the Washington Post. His book “The Paleo Cardiologist: The Natural Way to Heart Health” was an Amazon #1 best-seller.

Dr. Wolfson and his wife Heather have four children and are committed to making the world a better place to live. They provide for those in need (including animals) and support natural health causes through their philanthropic efforts.

Chiropractic

Our chiropractor is an expert at adjustments and holistic chiropractic care and works closely in conjunction with the other health care experts at Natural Heart Doctor.

Call (480) 535-6844 for details and scheduling.

IV Therapy

We use specially formulated natural vitamins and minerals that are injected into a vein to prevent or treat dehydration. Ideal for people in Arizona.

Call (480) 535-6844 for details and scheduling.

Acupuncture

Stimulate your body’s natural healing abilities and promote physical and emotional well-being with acupuncture at Natural Heart Doctor.

Call (480) 535-6844 for details and scheduling.

Health Coaching

Our health coaches use evidence based skillful conversation, clinical interventions, and strategies to engage you actively and safely in health behavior changes.

Call (480) 535-6844 for details and scheduling.

Cardio Tests

We use the most advanced testing in the world to assess heart health and to identify the root cause of your health issues.

Call (480) 535-6844 for details and scheduling.

Office Visits

Schedule an office visit with one of our cardiologists, holistic physicians, chiropractor, or health coaches.

Call (480) 535-6844 for details and scheduling.

Frequently Asked Questions

I’d like to receive an online second opinion from Natural Heart Doctor. What do I do next?

You can initiate a second opinion online through our website at any time. To begin, select the team member you’d like to speak with and open an account.

Click here for cardiologist Dr. Jack Wolfson.

Naturopathic Medical Doctor Dr. Lauren Lattanza. Get details.

Naturopathic Medical Doctor Dr. Tonia Rainier. Get details.

Click here for  Natural Heart Doctor Health Coach.

Alternatively, you can email health@naturalheartdoctor.com. A member of our care team will help guide you through the process of starting a second opinion.

What is the cost of a Natural Heart Doctor Online Second Opinion?

The cost for most second opinions varies by team member. This fee includes information collection, a phone or video consultation, a second opinion from a Natural Heart Doctor specialist and guidance throughout the process from your personal Care Team at Natural Heart Doctor.

Cardiologist Dr. Jack Wolfson’s Second Opinion Fee is $1500.

Holistic Physician’s Dr. Lauren Lattanza’s Second Opinion Fee is $250.

Naturopathic Physician Dr. Tonia Rainier’s Second Opinion Fee is $250.

Note: We apply the Online Second Opinion Call fee as a credit to any future consultations with Natural Heart Doctor, should you choose them.

Will my insurance cover the cost of a Natural Heart Doctor Online Second Opinion?

Most likely, no. Most health plans do not cover online second opinions or consultations. You are responsible for the cost of our second opinion. Natural Heart Doctor cannot file a claim with your insurance carrier, nor can we provide a procedure (CPT) code for this service.

What is the timeline to receive an online second opinion?

We do our best to schedule your second opinion as quickly as possible. Typically, it takes 5 to 7 business days after your information has been collected to receive your phone or video online second opinion.

What information do you need in advance of our call?

Our office will send you a short questionnaire to complete and return. We DO NOT need your complete medical records.

How many questions can I ask the expert during our call?

You may ask a maximum of five questions. This is to ensure that the expert has sufficient time to devote to each question. All questions must be finalized before your online meeting.

What should I expect to receive once my second opinion is complete?

You will receive a summary of our discussion along with our second opinion. The second opinion will be in written form. After you have reviewed the second opinion, a Natural Heart Doctor clinician will follow up with you by phone to address general medical questions about the information provided in the second opinion.

What if I have follow-up questions for the expert after I have reviewed my second opinion?

If you have a clarifying question about an expert’s response to one of the questions in your second opinion, and the Natural Heart Doctor clinician is unable to address it, then you may request a follow up session for an additional fee. 

Is my medical and payment information secure?

Natural Heart Doctor is strongly committed to protecting the privacy and security of all our patients. Our website meets all federal requirements for protecting personal health information under the Health Insurance Portability and Accountability Act (HIPAA). All financial transactions are processed by Natural Heart Doctor securely using industry standard payment processing tools.

I would rather visit Natural Heart Doctor for an in-person appointment. What should I do next?

If you would prefer an in-person appointment at Natural Heart Doctor instead of an online second opinion, please call (480) 535-6844 for details and scheduling.

Can I schedule a follow up appointment with the specialist who provided my online second opinion?

Yes, we’re happy to help you on an extended basis. Our clinician can discuss options with you when presenting our second opinion summary.