Why Some People Get Sick From Mold and Toxins… While Others Don’t

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Some People Get Sick From Mold and Toxins… While Others Don’t

Have you ever wondered why two people can live in the same home, breathe the same air, eat the same food… and yet only one of them develops symptoms?

One person feels fine.

The other struggles with fatigue, brain fog, palpitations, headaches, anxiety, or unexplained inflammation.

This is not random.

This is biology.

And the answer lies in three key areas:

  • Your genetics
  • Your toxic burden
  • Your body’s ability to respond

Let’s break this down.

The Missing Piece Most Doctors Ignore

Conventional medicine tends to look for disease once it is already present.
But it rarely asks a more important question:

Why did this person respond differently in the first place?

The truth is, your body is constantly exposed to toxins.

Mold, mycotoxins, environmental chemicals, heavy metals, and more.

The real issue is not exposure.

The issue is how your body handles that exposure.

The Role of Genetics

At the center of this conversation is a group of genes called HLA.

HLA stands for Human Leukocyte Antigen.

These genes control how your immune system recognizes threats.

Think of HLA as your body’s internal security system.

It scans your environment, identifies what does not belong, and alerts your immune system to remove it.

But here is the problem.

Not everyone has the same HLA system.

Why This Matters for Mold and Toxins

Certain HLA genetic patterns make it harder for the body to recognize toxins like mold.

When that happens, the body does not properly tag the toxin as dangerous.

Instead of clearing it, the toxin stays in circulation.

This leads to:

  • Persistent immune activation
  • Chronic inflammation
  • Ongoing oxidative stress

And eventually, symptoms.

This is why about one in four people are far more sensitive to mold exposure than others.

What Happens Inside the Body

When toxins are not properly recognized and cleared:

  • They recirculate through the body
  • They irritate blood vessels
  • They increase oxidative stress
  • They disrupt normal cellular function

Over time, this can impact:

  • Energy levels
  • Brain function
  • Hormonal balance
  • Cardiovascular health

This is where we begin to see connections between environmental toxicity and heart disease.

It’s Not Just One Gene

While HLA is the most important gene for immune recognition, it is not the only factor.

Other genes influence how well your body processes and eliminates toxins.

For example:

  • MTHFR affects methylation and detox pathways
  • GST genes support glutathione production and antioxidant defense
  • CYP enzymes help process environmental chemicals
  • NOS3 impacts nitric oxide and vascular health

If these pathways are impaired, the body becomes even more vulnerable.

The Real Difference Between People

Two people walk into the same mold-exposed building.

One feels nothing.

The other develops symptoms within days or weeks.

Why?

Because one person:

  • Recognizes the toxin
  • Processes it efficiently
  • Eliminates it effectively

And the other:

  • Fails to recognize it
  • Struggles to process it
  • Cannot clear it

This is not weakness.

This is biology.

Why This Matters for Your Heart

Chronic exposure to toxins that are not cleared properly leads to:

  • Inflammation
  • Oxidative stress
  • Endothelial dysfunction

These are the real drivers of cardiovascular disease.

Not simply cholesterol numbers.

When toxins linger in the body, they create a constant state of internal irritation.

And over time, that affects every system, including the heart.

Why Testing Matters

Most standard medical testing does not evaluate:

  • Genetic susceptibility
  • Toxin burden
  • Oxidative stress

This is why so many people are told everything looks normal… even when they feel terrible.

If you do not measure the problem, you cannot solve it.

At Natural Heart Doctor, we measure 100s of markers of health and sickness, giving you the information you need.

The Path Forward- Work with us. Click HERE for a free discovery call.

The goal is not to fear toxins.

The goal is to understand your body and support it.

That includes:

  • Identifying your genetic vulnerabilities
  • Assessing your toxic load
  • Supporting detox pathways
  • Reducing ongoing exposure
  • Improving your body’s resilience

When you do this, the body often does exactly what it was designed to do.

Heal.

If you want to take the next step, this is where we begin:

  • Advanced testing to identify oxidative stress and toxin burden
  • Personalized strategies based on your biology
  • Targeted nutrition and supplementation to support detox and vascular health

Because when you give the body what it needs, it gets the job done.

Click HERE for a free discovery call.

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About Dr. Keith Smigiel NP, DC

Dr. Keith Smigiel

Dr. Keith Smigiel is a regenerative medicine physician and pain management specialist. He takes an integrative approach to medicine, focusing on customized solutions tailored to individual needs. Using advanced, non-surgical treatments, Dr. Smigiel stimulates your body’s ability to naturally heal itself.

Dr. Smigiel helps people suffering from conditions such as chronic pain and erectile dysfunction, to hair loss and weight gain. Combining treatments such as PRP Therapy, Ozone, Neural Prolotherapy, and IV Infusions with functional rehabilitation, he helps you look and feel better.

He heals the body, instead of just treating the symptoms!

With his professional qualifications as a certified family nurse practitioner, a doctor of chiropractic, and a fellow of the International Academy of Medical Acupuncture, Dr. Smigiel offers patients comprehensive care from a broad perspective of conventional and alternative medicine. He also has extensive experience in functional rehabilitation and chronic pain management.

Dr. Smigiel is married to Angela and has two children, Sophia and Larz. When he’s not busy helping patients, he enjoys hiking, mountain biking, motocross, and boating.

About Dr. Lauren Lattanza NMD, FACC

Dr. Lattanza Office Visit with Patient

As a Naturopathic Physician, I am trained to treat the whole person and get to the root cause of disease.

I went to Arizona State University where I graduated with a bachelor’s degree in psychology with a depth in physiology and minor in Spanish. After my undergraduate degree I was working on prerequisite classes towards medical school, which is when I came to learn that my values identified best with the principles of naturopathic medicine. I knew that I wanted to help patients identify the causes of disease and be able to offer treatments which would improve their health rather than simply treating symptoms.

I dedicated the next 4 years to the Southwest College of Naturopathic Medicine in Tempe, Arizona where I attained my Doctorate of Naturopathic Medicine. I served as Class President all 4 years, Board of Trustees – Student Trustee, spoke as the Club President for our branch of Toastmasters, and was voted by my peers and attending physicians to earn the Outstanding Leadership Award for the Class of 2020. Throughout medical school I took it upon myself to work alongside MDs, DOs, chiropractors, and functional medicine practitioners in addition to naturopathic physicians.

As a Spanish speaking student, I was able to volunteer with community clinics around Phoenix and provide free healthcare to low-income families. Due to this combined exposure, I came to find my passion in treating cardiometabolic and digestive disorders that are all too common, yet largely preventable. I took the opportunity to learn the broad spectrum of healthcare so I can ensure that I am able to provide my patients with the best options.

About Dr. Jack Wolfson DO, FACC

Dr. Wolfson Office Visit with Patient

Dr. Jack Wolfson is a cardiologist, Amazon best-selling author, husband, father, and the nation’s #1 Natural Heart Doctor.

For more than two decades, more than one million people have enjoyed the warmth, compassion, and transformational power of his natural heart health courses and events.

Dr. Wolfson is the founder of Natural Heart Doctor Scottsdale, his heart health practice in Arizona, and Natural Heart Doctor, an online resource center with natural health information. Doctors from across the globe reach out to Dr. Wolfson for training and education in holistic health practices.

He has been named one of America’s Top Functional Medicine Doctors and is a five-time winner of the Natural Choice Awards as a holistic M.D. Dr. Wolfson’s work has been covered by more than 100 media outlets, including NBC, CNN, and the Washington Post. His book “The Paleo Cardiologist: The Natural Way to Heart Health” was an Amazon #1 best-seller.

Dr. Wolfson and his wife Heather have four children and are committed to making the world a better place to live. They provide for those in need (including animals) and support natural health causes through their philanthropic efforts.

Chiropractic

Our chiropractor is an expert at adjustments and holistic chiropractic care and works closely in conjunction with the other health care experts at Natural Heart Doctor.

Call (480) 535-6844 for details and scheduling.

IV Therapy

We use specially formulated natural vitamins and minerals that are injected into a vein to prevent or treat dehydration. Ideal for people in Arizona.

Call (480) 535-6844 for details and scheduling.

Acupuncture

Stimulate your body’s natural healing abilities and promote physical and emotional well-being with acupuncture at Natural Heart Doctor.

Call (480) 535-6844 for details and scheduling.

Health Coaching

Our health coaches use evidence based skillful conversation, clinical interventions, and strategies to engage you actively and safely in health behavior changes.

Call (480) 535-6844 for details and scheduling.

Cardio Tests

We use the most advanced testing in the world to assess heart health and to identify the root cause of your health issues.

Call (480) 535-6844 for details and scheduling.

Office Visits

Schedule an office visit with one of our cardiologists, holistic physicians, chiropractor, or health coaches.

Call (480) 535-6844 for details and scheduling.

Frequently Asked Questions

I’d like to receive an online second opinion from Natural Heart Doctor. What do I do next?

You can initiate a second opinion online through our website at any time. To begin, select the team member you’d like to speak with and open an account.

Click here for cardiologist Dr. Jack Wolfson.

Naturopathic Medical Doctor Dr. Lauren Lattanza. Get details.

Naturopathic Medical Doctor Dr. Tonia Rainier. Get details.

Click here for  Natural Heart Doctor Health Coach.

Alternatively, you can email health@naturalheartdoctor.com. A member of our care team will help guide you through the process of starting a second opinion.

What is the cost of a Natural Heart Doctor Online Second Opinion?

The cost for most second opinions varies by team member. This fee includes information collection, a phone or video consultation, a second opinion from a Natural Heart Doctor specialist and guidance throughout the process from your personal Care Team at Natural Heart Doctor.

Cardiologist Dr. Jack Wolfson’s Second Opinion Fee is $1500.

Holistic Physician’s Dr. Lauren Lattanza’s Second Opinion Fee is $250.

Naturopathic Physician Dr. Tonia Rainier’s Second Opinion Fee is $250.

Note: We apply the Online Second Opinion Call fee as a credit to any future consultations with Natural Heart Doctor, should you choose them.

Will my insurance cover the cost of a Natural Heart Doctor Online Second Opinion?

Most likely, no. Most health plans do not cover online second opinions or consultations. You are responsible for the cost of our second opinion. Natural Heart Doctor cannot file a claim with your insurance carrier, nor can we provide a procedure (CPT) code for this service.

What is the timeline to receive an online second opinion?

We do our best to schedule your second opinion as quickly as possible. Typically, it takes 5 to 7 business days after your information has been collected to receive your phone or video online second opinion.

What information do you need in advance of our call?

Our office will send you a short questionnaire to complete and return. We DO NOT need your complete medical records.

How many questions can I ask the expert during our call?

You may ask a maximum of five questions. This is to ensure that the expert has sufficient time to devote to each question. All questions must be finalized before your online meeting.

What should I expect to receive once my second opinion is complete?

You will receive a summary of our discussion along with our second opinion. The second opinion will be in written form. After you have reviewed the second opinion, a Natural Heart Doctor clinician will follow up with you by phone to address general medical questions about the information provided in the second opinion.

What if I have follow-up questions for the expert after I have reviewed my second opinion?

If you have a clarifying question about an expert’s response to one of the questions in your second opinion, and the Natural Heart Doctor clinician is unable to address it, then you may request a follow up session for an additional fee. 

Is my medical and payment information secure?

Natural Heart Doctor is strongly committed to protecting the privacy and security of all our patients. Our website meets all federal requirements for protecting personal health information under the Health Insurance Portability and Accountability Act (HIPAA). All financial transactions are processed by Natural Heart Doctor securely using industry standard payment processing tools.

I would rather visit Natural Heart Doctor for an in-person appointment. What should I do next?

If you would prefer an in-person appointment at Natural Heart Doctor instead of an online second opinion, please call (480) 535-6844 for details and scheduling.

Can I schedule a follow up appointment with the specialist who provided my online second opinion?

Yes, we’re happy to help you on an extended basis. Our clinician can discuss options with you when presenting our second opinion summary.